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This edition
, English, Article, Report
Study design and rationale of 'Influence of Cilostazol-based
triple anti-platelet therapy on ischemic complication after drug-eluting
stent implantation (CILON-T)' study: A multicenter randomized trial
evaluating the efficacy of Cilostazol on ischemic vascular complications
after drug-eluting stent implantation for coronary heart disease.(Study
protocol)(Clinical report)
Edition details
Study design and rationale of 'Influence of Cilostazol-based
triple anti-platelet therapy on ischemic complication after drug-eluting
stent implantation (CILON-T)' study: A multicenter randomized trial
evaluating the efficacy of Cilostazol on ischemic vascular complications
after drug-eluting stent implantation for coronary heart disease.(Study
protocol)(Clinical report)
Also Titled
Study design and rationale of 'Influence of
Cilostazol-based triple anti-platelet therapy on ischemic complication
after drug-eluting stent implantation (CILON-T)' study: A
multicenter randomized trial evaluating the efficacy of Cilostazol on
ischemic vascular complications after drug-eluting stent implantation
for coronary heart disease.
Appears In
Trials, v.11, 2010 August 24, p.87 (ISSN: )
Lee, Seung-Pyo
Suh, Jung-Won
Park, Kyung Woo
Lee, Hae-Young
Kang, Hyun-Jae
Koo, Bon-Kwon
Chae, In-Ho
Choi, Dong-Ju
Rha, Seung-Woon
Bae, Jang-Whan
Cho, Myeong-Chan
Kwon, Taek-Geun
Bae, Jang-Ho
Kim, Hyo-Soo
BioMed Central Ltd., 2010 August 24
Physical Description
6038 words
Clinical report
Magazine/Journal article
Target Audience
Background
Current guidelines recommend dual anti-platelet therapy, aspirin
and clopidogrel, for patients treated with drug-eluting stent for
coronary heart disease. In a few small trials, addition of cilostazol on
dual anti-platelet therapy (triple anti-platelet therapy) showed better
late luminal loss. In the real-world unselected patients with coronary
heart disease, however, the effect of cilostazol on platelet reactivity
and ischemic vascular events after drug-eluting stent implantation has
not been tested. It is also controversial whether there is a significant
interaction between lipophilic statin and clopidogrel.
Methods/Design
CILON-T trial was a prospective, randomized, open-label,
multi-center, near-all-comer trial to demonstrate the superiority of
triple anti-platelet therapy to dual anti-platelet therapy in reducing 6
months' major adverse cardiovascular/cerebrovascular events,
composite of cardiac death, nonfatal myocardial infarction, target
lesion revascularization and ischemic stroke. It also tested whether
triple anti-platelet therapy is superior to dual anti-platelet therapy
in inhibiting platelet reactivity in patients receiving percutaneous
coronary intervention with drug-eluting stent. Total 960 patients were
randomized to receive either dual anti-platelet therapy or triple
anti-platelet therapy for 6 months and also, randomly stratified to
either lipophilic statin (atorvastatin) or non-lipophilic statin
(rosuvastatin) indefinitely. Secondary endpoints included all components
of major adverse cardiovascular/cerebrovascular events, platelet
reactivity as assessed by VerifyNow P2Y12 assay, effect of statin on
major adverse cardiovascular/cerebrovascular events, bleeding
complications, and albumin-to-creatinine ratio to test the
nephroprotective effect of cilostazol. Major adverse
cardiovascular/cerebrovascular events will also be checked at 1, 2, and
3 years to test the 'legacy' effect of triple anti-platelet
therapy that was prescribed for only 6 months after percutaneous
coronary intervention.
Discussion
CILON-T trial will give powerful insight into whether triple
anti-platelet therapy is superior to dual anti-platelet therapy in
reducing ischemic events and platelet reactivity in the real-world
unselected patients treated with drug-eluting stent for coronary heart
disease. Also, it will verify the laboratory and clinical significance
of drug interaction between lipophilic statin and clopidogrel.
Trial Registration
National Institutes of Health Clinical Trials Registry
(ClinicalTrials.gov identifier# NCT).
Terms of Use
COPYRIGHT 2010 BioMed Central
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comments or reviews for this versionMinecraft - 歌单 - 网易云音乐
emmm。。这是个mc的歌单(??ω??)??
1~24首来自《Minecraft Volume Alpha》( o ?ωo? )?
25~54首来自《Minecraft Volume Beta》(*'▽'*)?
55~71首是游戏扩展包《中国神话》的原声带⊙▽⊙
72~86首是...
emmm。。这是个mc的歌单(??ω??)??
1~24首来自《Minecraft Volume Alpha》( o ?ωo? )?
25~54首来自《Minecraft Volume Beta》(*'▽'*)?
55~71首是游戏扩展包《中国神话》的原声带⊙▽⊙
72~86首是以太mod原声带(?◇?)
从第87首开始是mc的各种同人曲?(?????)?
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