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Dr. Steven D. Sosler*, Bernard J. Jilly, Catherine Saporito andMabel KoshyDOI:&10.1002/ajh.
American Journal of Hematology pages 103&106, Author InformationThe University of Illinois College of Medicine, Departments of Pathology and Medicine, Chicago, Illinois*Department of Pathology, University of Illinois College of Medicine, 1853 West Polk Street, Chicago, IL 60612Publication HistoryIssue online: 11 JUL 2006Version of Record online: 11 JUL 2006Manuscript Accepted: 12 NOV 1992Manuscript Received: 6 NOV 1992
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transfusionAbstractPatients with sickle cell disease (SCD) form immune alloantibodies more frequently than other transfused populations because red cells (RBCs) from white donors (with a higher incidence of certain Rh, Duffy, Kell, and Kidd blood group antigens) are transfused to black patients often lacking these antigens. We propose a model to reduce alloimmunization in patients with SCD by providing them with blood from only black random donors. Rationale is shown by examining calculations based on the phenotype E&, C&, Fy(a&), K&, and Jk(b&). There is a 7% probability that this phenotype belongs to a white donor, while there is a 93% probability that this phenotype belongs to a black donor. The probability of selecting blood from a black donor identical with the above phenotype for black recipients from an all black population and from a typical urban blood inventory population (90% white, 10% black) is 1/4 and 1/33, respectively. Therefore, an 8-fold greater chance of selecting antigen non-identical blood occurs if blood is obtained from a typical urban donor population as compared to a black population. Based on these calculations, alloimmunization can be reduced prospectively in patients with SCD by meeting their transfusion requirements with blood selected from random black blood donors.推荐这篇日记的豆列
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